However, the authors did not find statistical differences when considering other research outputs, such as the frequency and intensity of pain. On the contrary, there are certain alternatives, such as the intestinal biopsy, the histamine provocation test or the histamine metabolomics in urine, that could make it possible to diagnose histamine intolerance due to DAO deficiency without excluding any of the possible etiological causes. The clinical management is carried out mainly through the follow-up of a low-histamine diet, although there is no consensus on the list of foods to be excluded. Genetic variability of human diamine oxidase: Occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activity. histamine receptors. A wide variability of the DAO capacity of porcine kidney extracts has been reported (with values ranging from 0.1 to more than 100 mU/mg), depending on the purification grade applied to the matrix and/or the amine compound used as the reaction substrate [57,129,130,131,132,133]. In the study by Wöhrl et al., half of the healthy volunteers developed symptoms after the administration of a solution containing 75 mg of histamine [107]. Panula P., Chazot P.L., Cowart M., Gutzmer R., Leurs R., Liu W.L.S., Stark H., Thurmond R.L., Haas H.L. In vitro experimental results show a potent inhibitory effect (greater than 90%) of chloroquine, a historical antimalarial active ingredient, and clavulanic acid, a β-lactam antibiotic widely used in combination with amoxicillin [80]. Rosell-Camps A., Zibetti S., Pérez-Esteban G., Vila-Vidal M., Ramis L.F., García-Teresa-García E., Ferrés-Ramis L., García-Teresa-García E. Intolerancia a la histamina como causa de síntomas digestivos crónicos en pacientes pediátricos. [63]. The measurement of intestinal DAO activity by a colon biopsy during endoscopic procedures has been studied as a possible diagnostic marker. Izquierdo-Casas J., Comas-Basté O., Latorre-Moratalla M.L., Lorente-Gascón M., Duelo A., Soler-Singla L., Vidal-Carou M.C. The FAO and WHO have acknowledged that the involvement of potentiators can alter the threshold dose for toxicity, and they recommend that future studies focus on clarifying the ambiguities in the pathogenesis of histamine intoxication [30]. Tuck C.J., Biesiekierski J.R., Schmid-Grendelmeier P., Pohl D. Food Intolerances. Similar to the current treatment for lactose intolerance, the possibility of oral supplementation with exogenous DAO has been proposed by several authors to facilitate dietary histamine degradation [13,127].
Johanniskraut - kritische Substanz? - Symptome, Ursachen von Krankheiten Colombo F.M., Cattaneo P., Confalonieri E., Bernardi C. Histamine food poisonings: A systematic review and meta-analysis. In this context, in the update of the official list of novel foods in 2017, the European Commission gave the green light to the marketing of a DAO supplement as food supplement or as food for special medical purposes [128]. HHS Vulnerability Disclosure, Help Licensee MDPI, Basel, Switzerland. Etiologically, various SNPs have been identified in the gene encoding the DAO enzyme related to lower enzyme activity. Translations may contain older or less detailed information than the original German page! Latorre-Moratalla M.L., Comas-Basté O., Bover-Cid S., Vidal-Carou M.C. Laurenzi M., Tipping A.J., Marcus S.E., Knox J.P., Federico R., Angelini R., McPherson M.J. and Izquierdo-Casas et al. Deswegen sollten koffeinhaltige Getränke besser gemieden werden. Overall, despite the promising results, more ambitious clinical studies with a rigorous experimental design, longer treatment periods and properly sized samples are essential to establish the clinical efficacy of this treatment. Von einer Histaminintoleranz sind zu achtzig Prozent Frauen im mittleren Alter betroffen. Other foods such as spinach, eggplant and tomatoes should also be avoided for the same reason. reported a strong association between reduced DAO activity and the presence of NCGS, although with a reduced number of patients [77,78]. In the diet follow-up, a thorough 24-h record of all the foods consumed and symptoms experienced is recommended in order to establish a relationship, if any, between a food and the onset of symptoms [10,13]. The low specificity and complex variability of symptoms undoubtedly contribute to the current difficulty in achieving consensus on the diagnostic criteria for histamine intolerance, as will be discussed in detail below [13]. Serum diamine oxidase activity is associated with lactose malabsorption phenotypic variation. García-Martín E., García-Menaya J., Sánchez B., Martínez C., Rosendo R., Agúndez J.A.G. The DAO enzyme was first identified back in 1929 by Charles H. Best in autolyzing lung tissue, which he called histaminase because of its ability to degrade histamine [56]. During the last decade, histamine intolerance has gained social and scientific recognition, with a significant increase in the interest of researchers to investigate this disorder. In this context, it is necessary to keep promoting the multidisciplinary study of this disorder, both from basic (i.e., analytical chemistry, food science, physiology and biochemistry) and clinically applied research, meant to increase the scientific base and the currently available diagnostic and treatment strategies for histamine intolerance. Kaur S., Ali A., Siahbalaei Y., Ahmad U., Nargis F., Pandey A.K., Singh B. The most recent data from the EFSA and European Center for Disease Prevention and Control (ECDC) show that in 2017, there was a 22% increase in outbreaks compared to the previous year [50]. Wer an Zöliakie, einer Allergie gegen das in der Lauge enthaltene Natriumhydroxid oder Histaminintoleranz leidet, könnte beim Verzehr der Backware Nebenwirkungen spüren. Pietrangeli P., Federico R., Mondovì B., Morpurgo L. Substrate specificity of copper-containing plant amine oxidases. If proven, this diagnostic test would be very adequate since this disorder originates from a reduced ability of the intestinal DAO enzyme to cope with dietary histamine. This review aims to analyze the pathophysiological relevance of dietary histamine, giving special focus to the adverse effects derived from histamine intake and, in particular, to the state of the art concerning the etiology, diagnosis and treatment of histamine intolerance. In contrast, Guida et al., Wagner et al. Natriumhydroxid Eigenschaften. Masini E., Bani D., Marzocca C., Mateescu M.A., Mannaioni P.F., Federico R., Mondovì B. Pea seedling histaminase as a novel therapeutic approach to anaphylactic and inflammatory disorders: A plant histaminase in allergic asthma and ischemic shock. Histamine metabolism in humans. Zuberbier T., Aberer W., Asero R., Abdul Latiff A.H., Baker D., Ballmer-Weber B., Bernstein J.A., Bindslev-Jensen C., Brzoza Z., Buense Bedrikow R., et al. More recently, two studies have been published specifically focused in investigating the in vitro DAO activity of porcine kidney protein extract expressly used as active ingredient to formulate food supplements for the preventive treatment of histamine intolerance [129,130]. Improved purification and properties. Lack of association of plasma histamine with diamine oxidase in chronic idiopathic urticaria. Histamine content in different food categories. Mušič et al. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (, histamine, food intolerance, histamine intolerance, histaminosis, histamine intoxication, diamine oxidase (DAO), low-histamine diet, food supplement. In fact, Griauzdaite et al. Microbiol. Eigenschaften. In contrast, three studies did not find a significant relationship between the clinical history of patients with typical symptoms of histamine intolerance and blood DAO activity values, concluding that this technique cannot be recommended as a diagnostic tool in routine clinical practice until studies have validated its effectiveness [98,99,100]. Analysis of the distribution of copper amine oxidase in cell walls of legume seedlings. Finally, several authors have reported considerable interindividual variability in histamine tolerance, which has been demonstrated in intervention studies [1,3,10,13]. Wolvekamp M.C.J., de Bruin R.W.F. all point out an increase in plasma enzymatic activity in more than 50% of patients after the dietary intervention, although no explanatory hypothesis has been yet suggested [83,85,86,123]. Purification of pig kidney diamine oxidase by gel-exclusion chromatography. Several authors have proposed that alcohol and certain food components, such as other biogenic amines, may have a potentiating effect on histamine toxicity [13,48]. sodium hydroxide (NaOH), also called caustic soda or lye, a corrosive white crystalline solid that contains the Na + ( sodium) cation and the OH − ( hydroxide) anion. Natriumhydroxid (auch Ätznatron, kaustische (s) Soda ), chemische Formel NaOH, ist ein weißer hygroskopischer Feststoff. Schnedl W.J., Lackner S., Enko D., Schenk M., Mangge H., Holasek S.J. Biogenic amines in foods. Eine Brezel enthält laut "Stiftung Warentest" etwa 1,5 Gramm Salz. In: Salas-Salvadó J., Bonadai Sanjaume A., Trallero-Casañas R., Saló i Solà M.E., Burgos-Peláez R., editors.
Histamine intolerance: Causes, symptoms, and test - Medical News Today Foods that potentially contain high levels of histamine are: a) those microbiologically altered, such as fish and meat, or derived products that may have been preserved or processed in unsuitably hygienic conditions; and b) fermented products, in which the bacteria responsible for the fermentation process may also have aminogenic capacity [3,40]. Visciano P., Schirone M., Tofalo R., Suzzi G. Histamine poisoning and control measures in fish and fishery products. Joseph P., Srivastava S.K. Years later, given its ability to also degrade other diamines, as described above, the more accurate designation of DAO was proposed [57,58]. Comas-Basté O., Luz Latorre-Moratalla M., Sánchez-Pérez S., Teresa Veciana-Nogués M., del Carmen Vidal-Carou M. Histamine and Other Biogenic Amines in Food. Potentiation by aminoguanidine of the sensitivity of sheep to histamine given by mouth. Kofler L., Ulmer H., Kofler H. Histamine 50-Skin-Prick Test: A Tool to Diagnose Histamine Intolerance. The diagnosis of histamine intoxication is based primarily on the determination of elevated plasma histamine levels and/or the identification of an ingested food with an unusually high histamine content [13]. This research received no external funding. This recently indicated relationship between both disorders, NCGS and histamine intolerance, should be further explored as it may be of interest for the correct clinical management of affected patients. XCVIII. The effectiveness of a low-histamine diet has been demonstrated in clinical studies, which report favorable results in terms of improvement or total remission of symptoms frequently associated with histamine intolerance and DAO deficiency (Table 4). German guideline for the management of adverse reactions to ingested histamine. Synthesis of histamine by decarboxylation of its precursor amino acid. Oxidative deamination of histamine by the DAO enzyme. Although there is some variability, the available research points to the effectiveness of DAO supplements in reducing the appearance and intensity of symptoms. Browse Natriumhydroxid and related . Klocker J., Mätzler S.A., Huetz G.-N., Drasche A., Kolbitsch C., Schwelberger H.G. Maintz L., Benfadal S., Allam J.P., Hagemann T., Fimmers R., Novak N. Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema. Overall, following any of the exclusion diets resulted in the total or partial remission of symptoms in 4.9% and 37.5% of patients, respectively. (00:52) Natriumhydroxid Verwendung. Improving intestinal DAO activity would allow a less restrictive diet, which could include foods with a tolerable dose of histamine [10,61]. It is highly soluble in water, with a lower solubility in polar solvents such as ethanol and methanol. Histamine is a chemical that sends messages to the brain, signals the release of stomach acid for digestion, and is released as part of the immune system's response to an injury or allergic . Histamin kommt in bestimmten Lebensmitteln vor. Inflamm. If these conditions are negative, the appearance of two or more typical symptoms of histamine intolerance and their improvement or remission after the following of a low-histamine diet (i.e., a diet excluding foods that, a priori, contain high histamine levels) will confirm the diagnosis of histamine intolerance [10,54,96,97]. Infolgedessen kommt es zu möglichen Symptomen wie Quaddeln auf der Haut, Juckreiz, Kopfschmerzen und Magen-Darm-Beschwerden. Elsenhans B., Hunder G., Strugala G., Schümann K. Longitudinal pattern of enzymatic and absorptive functions in the small intestine of rats after short-term exposure to dietary cadmium chloride. The evidence for the validity of blood DAO activity measurements for the diagnosis of histamine intolerance is neither abundant nor conclusive. The gateway for dietary histamine in the body is the intestinal epithelium. Without disputing the clinical entity of histamine intoxication, the paradigm shift lies precisely in moving the focus from food to the human body, maintaining histamine as the causative agent, but focusing on how each person is able to respond to the intake of variable levels of histamine from food. Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Asso. Sodium hydroxide is the most widely used industrial alkali and is often used in drain and oven cleaners. Overall, in spite of the varying percentages in DAO deficiency, the currently available studies seem to indicate an etiological relationship between DAO deficiency and certain symptoms or disorders related to histamine intolerance. Specifically, in 2017, there were a total of 117 outbreaks of histamine intoxication involving 572 people, 9% of whom required hospitalization. Histamine intolerance is currently a clinical entity of increasing interest, which can appear due to the intake of histamine from foods, mainly caused by a deficiency of the DAO enzyme at the intestinal level. Histamine intolerance, also referred to as enteral histaminosis or sensitivity to dietary histamine, can be defined as a disorder arising from reduced histamine degradation capacity in the intestine due to impaired DAO activity, leading to its accumulation in plasma and the appearance of adverse effects [11,41,55]. Kuefner M.A., Schwelberger H.G., Hahn E.G., Raithel M. Decreased histamine catabolism in the colonic mucosa of patients with colonic adenoma. Regarding migraines, the randomized double-blind clinical trial conducted by Izquierdo et al. Leitner R., Zoernpfenning E., Missbichler A. Boehm T., Pils S., Gludovacz E., Szoelloesi H., Petroczi K., Majdic O., Quaroni A., Borth N., Valent P., Jilma B. Quantification of human diamine oxidase. Manche Menschen reagieren auf Histamin mit allergieähnlichen Beschwerden wie Rötung der Haut, Juckreiz, Schnupfen, Niesen oder Kopfschmerz. Lessof M.H., Gant V., Hinuma K., Murphy G.M., Dowling R.H. Recurrent urticaria and reduced diamine oxidase activity.
Natron trinken: Gesundes Hausmittel mit Nebenwirkungen Komericki P., Klein G., Reider N., Hawranek T., Strimitzer T., Lang R., Kranzelbinder B., Aberer W. Histamine intolerance: Lack of reproducibility of single symptoms by oral provocation with histamine: A randomised, double-blind, placebo-controlled cross-over study. Latorre-Moratalla M.L., Bover-Cid S., Bosch-Fusté J., Vidal-Carou M.C. Van Gelderen C.E.M., Savelkoul T.J.F., van Ginkel L.A., van Dokkum W. The effects of histamine administered in fish samples to healthy volunteers. Although the first scientific references to histamine intolerance date from more than 20 years ago, it is significant that almost 80% are from the last decade, reflecting the growing interest of researchers in this disorder (Figure 5).
Natriumhydroxid - Wikipedia Maintz L., Novak N. Histamine and histamine intolerance. Specifically, 10 of the 13 studies reviewed found an improvement in symptoms in more than 50% of patients who followed the diet; two studies show success rates of less than 50% (33% and 46%), and only one did not observe any beneficial effects (Table 4). It readily absorbs moisture until it dissolves. Ladero V., Calles-Enriquez M., Fernandez M., Alvarez M.A.
Natriumhydroxid (NaOH) Eigenschaften, Risiken und Nutzen The accumulation of these compounds in food is the result of the transformation of amino acids by microorganisms and depends on various factors, such as the availability of the precursor amino acids and environmental conditions favorable for growth and/or the bacterial decarboxylase activity [31,34,35]. Effect of diet in chronic spontaneous urticaria: A systematic review. Histamine intolerance, sometimes called histaminosis, [1] is an over-accumulation of dietary histamine in the human body. On the contrary, García-Martín et al. Moreover, Schnedl et al. Kettner L., Seitl I., Fischer L. Evaluation of porcine diamine oxidase for the conversion of histamine in food-relevant amounts. Doeun D., Davaatseren M., Chung M.S. Although certain studies have limitations, either in the design or number of participants, the majority point to an association between symptoms and DAO deficiency, establishing a general trend that supports the key role of DAO in the etiology of these disorders. Kofler H., Aberer W., Deibl M., Hawranek T., Klein G., Reider N., Fellner N. Diamine oxidase (DAO) serum activity: Not a useful marker for diagnosis of histamine intolerance. Schnedl W.J., Enko D. Considering histamine in functional gastrointestinal disorders. Natriumhydroxid löst sich unter starker Wärmebildung sehr gut in Wasser. Joneja J.M.V., Carmona-Silva C. Outcome of a histamine-restricted diet based on chart audit. Supplementation with exogenous DAO has recently been postulated as a complementary treatment to enhance dietary histamine degradation in intolerant individuals who have a deficiency of this enzyme in the intestine [109,110]. The exclusion of foods could be based on their content of other biogenic amines, such as putrescine and cadaverine, which act as competitive substrates for DAO and may therefore inhibit intestinal degradation of histamine if present in significant quantities [1,82]. #1 Hallo zusammen, hat einer von Euch Informationen oder Erfahrungen mit Johanniskraut im Zusammenhang mit HI? have recently developed a rapid and reliable methodology through ultra-high performance liquid chromatography and fluorimetric detection (UHPLC-FL) for the in vitro determination of DAO activity specifically for the analysis of unpurified complex matrixes, such as porcine kidney extract and DAO supplements [129]. Thus, a genetic origin would lead to a reduction of the DAO enzymatic activity in the whole organism. Received 2020 Jul 28; Accepted 2020 Aug 11. The physiological and pathophysiological effects of histamine on the body were first described in 1910 by Dale and Laidlaw, two pioneering researchers who studied the functions of this organic compound at the Wellcome Physiological Research Laboratories [4,5,6]. In diesem Beitrag lernst du alles über seine Eigenschaften, Verwendung und Herstellung. Legroux R., Levaditi J., Segond L. Methode de mise en evidence de l’histamine dans les aliments causes d’intoxications collectives a l’aide de l’inoculation au cobaye. also evaluated the changes in plasmatic DAO activity, reporting a slight increase in 61% of patients during the intervention, which the authors linked to a possible improvement in the integrity of the intestinal mucosa due to the supplementation [109]. In the absence of a consensual and clinically validated diagnosis, Figure 7 shows a schematic summary of the diagnostic algorithm for histamine intolerance based on the available scientific evidence reviewed below. A range of nonvalidated complementary tests have also been proposed by several authors with the aim of obtaining a marker to confirm the diagnosis [97]. To date, little data is available on the prevalence of this enzymatic deficiency related to gender, and it is inconclusive. Historically, histamine intoxication has also been termed scombroid fish poisoning or the mahi-mahi flush because of its repeated association with the consumption of fish in the Scombridae and Scomberesocidae families (e.g., tuna, herring and mackerel) [43]. Floris G., Fadda M.B., Pellegrini M., Corda M., Agro’ A.F. Ede G. Histamine intolerance: Why freshness matters? Natriumhydroxid löst sich auch in Ethanol oder . Clinical manifestations of histamine intolerance consist of a wide range of nonspecific gastrointestinal and extraintestinal symptoms, due to the ubiquitous distribution of the four histamine receptors in different organs and tissues of the body (Figure 6) [10,13,54,61]. In Wasser löst es sich unter großer Wärmeentwicklung durch die negative Lösungsenthalpie von −44,5 kJ/mol zur stark alkalisch reagierenden Natronlauge auf (pH 14 bei c = 1 mol/l). (01:36) Natriumhydroxid Herstellung. Currently, there is already the possibility of performing a noninvasive genetic analysis capable of identifying three of the SNPs associated with reduced DAO activity (i.e., rs10156191, rs1049742 and rs1049793) from a sample of the oral mucosa, although evidence-based studies on the diagnosis potential of this test are still needed. Currently, international health administrations consider histamine intoxication to be one of the main problems of global food security, both for its effects on human health and its impact on trade [47,48]. Oligomannosidic glycans at asn-110 are essential for secretion of human diamine oxidase. Histamine-reduced diet and increase of serum diamine oxidase correlating to diet compliance in histamine intolerance. NaOH. Inclusion in an NLM database does not imply endorsement of, or agreement with, In terms of incidence, the data available for the European Union shows an increase in histamine intoxication outbreaks in the last ten years, unlike other types of food poisoning, and with an almost hegemonic predominance of fish as the causative agent (over 90% of cases) [42,50]. The disappearance of histamine from autolysing lung tissue. [8] Inhaltsverzeichnis 1 Herstellung Thus, DAO activity has been proposed as a marker of integrity of the intestinal mucosa. Although interest in histamine intolerance has considerably grown in recent years, more scientific . Histamine intolerance (HIT) is the term for that type of food intolerance which . Massive release of the histamine-degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients. Empirical Valence Bond Simulations Suggest a Direct Hydride Transfer Mechanism for Human Diamine Oxidase. The potentiation effect of these components could help explain the differences in absorption of the same dose of histamine when ingested in isolation or in a food matrix [48,49]. Properties Physical properties Pure sodium hydroxide is a colorless crystalline solid that melts at 318 °C (604 °F) without decomposition and with a boiling point of 1,388 °C (2,530 °F). This article will provide an updated review on histamine intolerance, mainly focusing on its etiology and the existing diagnostic and treatment strategies. were focused on a single disorder related to histamine intolerance (chronic spontaneous urticaria and migraine, respectively) [110,144]. Selbst der DAO-Wert im Blut gibt darüber keinen . did describe differences in plasma DAO activity by gender, with the prevalence of this enzyme deficiency being higher in women [94]. Although this test has interesting diagnostic potential, more studies are needed to validate its clinical significance and its relationship with the symptoms of histamine intolerance [97]. Boehm T., Reiter B., Ristl R., Petroczi K., Sperr W., Stimpfl T., Valent P., Jilma B. Außerdem bewirkt Koffein, dass körpereigene Histaminspeicher ausgeschüttet werden. From a commercial point of view, having a plant source of this enzyme would expand the target of this novel food for the vegetarian/vegan population, as well as those with religious restrictions on the consumption of pork products. Structure and inhibition of human diamine oxidase. Intolerancia a la Histamina e Hipersensibilidad a Aditivos Alimentarios. Comas-Basté O., Latorre-Moratalla M.L., Bernacchia R., Veciana-Nogués M.T., Vidal-Carou M.C. A variant of the intradermal skin allergy test called the histamine 50-skin-prick test was also proposed by Kofler et al. Other substances have also shown an inhibitory effect, albeit to a lesser extent (Table 2) [23,80,81]. This controversy is described in a joint article published in 2017 by the German and Swiss allergology societies, which emphasizes the need for more research before giving plasma DAO activity a definitive diagnostic value for histamine intolerance [97]. Functionally, this amine is involved in various immune and physiological mechanisms, stimulating gastric acid secretion, inflammation, smooth muscle cell contraction, vasodilation and cytokine production, among other processes [8,9,10,11]. Gardini F., Özogul Y., Suzzi G., Tabanelli G., Özogul F. Technological factors affecting biogenic amine content in foods: A review. Lackner S., Malcher V., Enko D., Mangge H., Holasek S.J., Schnedl W.J. and Schnedl et al. The hypothesis is that individuals with histamine intolerance could have a different excretion profile of histamine and its metabolites in urine than normal individuals. As it may be seen in Table 3, there is no coincidence in all the foods excluded in the different low-histamine diets found in the literature [10,87,91,112,113,114,115,116,117,118]. Motil K.J., Scrimshaw N.S. Amines such as putrescine and cadaverine, which are usually found in foods along with histamine, can also act as DAO substrates. McGrath A.P., Hilmer K.M., Collyer C.A., Shepard E.M., Elmore B.O., Brown D.E., Dooley D.M., Guss J.M. The protective effect of DAO has been demonstrated in animal experimentation models that were administered aminoguanidine for irreversible and selective DAO inhibition, followed by a dose of histamine [24,27,28]. Although few works have assayed the clinical efficacy of this preventive treatment, promising results have been obtained so far. Effect of aminoguanidine on the urinary excretion of endogenous histamine. Wöhrl S., Hemmer W., Focke M., Rappersberger K., Jarisch R. Histamine intolerance-like symptoms in healthy volunteers after oral provocation with liquid histamine. Highlighting the complexity of the clinical picture of histamine intolerance, combinations of three or more symptoms involving different organs were recorded in 97% of cases, with an average of 11 symptoms per patient. Active ingredients with an experimentally demonstrated inhibitory effect on the DAO enzyme [23,28,80,81]. Likewise, the study performed by Izquierdo et al. Regarding DAO activity, the studies published by Steinbrecher et al., Maintz et al., Mušič et al. Schwelberger H.G., Feurle J., Houen G. Mapping of the binding sites of human histamine N-methyltransferase (HNMT) monoclonal antibodies. Natriumhydroxid ist bei physiologischem pH-Wert nach den wenigen vorliegenden Tests nicht genotoxisch.
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